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ACRO Biosystems Protein Resource for TIGIT Signaling Axis 2017-06-15 13:59:23



 

TIGIT (T cell immunoreceptor with Ig and ITIM domains) is a newly discovered immune checkpoint expressed on T cells and Natural Killer cells (NK). TIGIT is an inhibitory receptor which modulates the immune activity by competing with activating receptor CD226 (also known as DNAM1) for ligand binding. This on and off switch of TIGIT&DNAM1 parallels that of CTLA4&CD28, which makes it a promising target for anti-tumor therapy.

 

The ligands for TIGIT and DNAM1 including CD155 (PVR), also to CD112 (PVRL2 or Nectin 2), and CD113 (PVRL3 or Nectin 3). The affinity between different ligands and receptors vary. The binding between TIGIT and CD155 is more robust than that between TIGIT and CD112 or CD113.

 
 

 

ACROBiosystems carries a large collection of recombinant proteins from TIGIT signaling axis. In addition to the commonly used his and Fc tagged proteins, we also carry multiple pre-biotinylated proteins such as Biotinylated Human TIGIT, Avi Tag (Avitag™) (Cat. No. TIT-H82E5) Biotinylated Human CD155/PVR Protein, Fc Tag, Avi Tag (Avitag™) (Cat. No. CD5-H82F6) and Biotinylated Human Nectin-2/CD112 Protein, Fc Tag, Avi Tag (Avitag™) (Cat. No. CD2-H82F8). Please find detailed information below:

 

 

Immobilized Human CD155, Fc Tag (Cat. No. CD5-H5251) at 10 μg/mL (100 μL/well) can bind Biotinylated Human TIGIT, His Tag (Cat. No. TIT-H82E5) with a linear range of 0.08-0.31 μg/mL.

 
 

 

 Molecule 
Species
Cat. No.
Product Description
 TIGIT 
Rat   
TIT-R5258
Rat TIGIT Protein, Fc Tag 
Exclusive
 TIGIT 
Rabbit 
TIT-R5259
Rabbit TIGIT Protein, Fc Tag 
Exclusive
 TIGIT 
Cynomolgus 
TIT-C5223
Cynomolgus / Rhesus macaque TIGIT 
Exclusive
  TIGIT  
Human 
TIT-H82E5

Biotinylated Human TIGIT Protein,
Avi Tag (Avitag
)  

Exclusive
TIGIT
Human 
TIT-H5253
Human TIGIT Protein,
Mouse IgG2a Fc Tag, low endotoxin

Exclusive
TIGIT
 Mouse 
TIT-M52E6
Mouse TIGIT Protein
Exclusive
 
 

 Molecule 
Species
Cat. No.

                   Product Description

CD155
Human 
CD5-H82F6
Biotinylated Human CD155 / PVR Protein, Fc Tag, Avi Tag (Avitag)    
Exclusive
CD112  
Human 
CD2-H82F8
Biotinylated Human Nectin-2 / CD112 Protein, Fc Tag, Avi Tag (Avitag)
Exclusive
CD113  
Human 
PV3-H82F3
Biotinylated Human Nectin-3 / CD113 Protein, Fc Tag, Avi Tag (Avitag)
Exclusive
DNAM1  
Human 
DN1-H82F9
Biotinylated Human DNAM-1 / CD226 Protein, Fc Tag, Avi Tag (Avitag)  
Exclusive
 
 
                                                 

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