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BIOCARE Medical Key Antibodies For Infectious Diseases 2017-06-15 15:16:50



 
Key Antibodies For Infectious Diseases

Millions of patients visit physician offices for infectious and parasitic diseases each year. Approximately two-thirds of the world’s population is infected with H. pylori. In the United States for 2012, there were 10,000 new cases of tuberculosis and 31,000 new cases of Lyme disease. New cases of sexually transmitted diseases for the United States in 2012 include 14 million cases of HPV and 50,000 cases of syphilis. It is estimated that one out of every six people aged 14 to 49 have genital herpes in the United States. About 50-80% of United States women have been infected with CMV by the age of 40 years. Biocare Medical is proud to offer key infectious antibodies that may aid in the identification of their respective proteins by IHC in FFPE tissues.

 

Key Antibodies for Infectious Diseases

 

 

Key Antibodies for Infectious Diseases

 

Cat Scratch Fever (Bartonella henselae)

The causative bacterial agent of cat scratch disease has been identified as Bartonella henselae. Originally, complicated silver stains and/or PCR were used to identify and confirm this agent. This monoclonal Cat Scratch antibody aids to identify Bartonella henselae (and not other Bartonella strains) in FFPE tissues.

 

Cytomegalovirus (CMV)

Cytomegalovirus (CMV) can exacerbate gastrointestinal mucosal injury and affect fetuses. IHC performed on infected tissue directed against the CMV immediate early antigen is the gold standard for diagnosis. This antibody cocktail reacts with immediate early and early protein antigens in infected tissues.

 
 

Helicobacter pylori

Helicobacter pylori are spiral-curved, gramnegative bacteria that is present on surface epithelium of the mucous layer of the stomach. IHC with a specific antibody can distinguish H. pylori from other types of curved bacteria. These bacteria may play a significant role in peptic ulcer disease.

 
 
 

Herpes Simplex Virus 1 (2X)

This antibody reacts with Herpes Simplex Virus (HSV) 1. HSV reacts with major viral envelope glycoproteins and with core proteins. Typically, HSV Type 1 infects tissues such as lung and esophagus. It does not cross-react with CMV, Epstein-Barr virus, or varicella zoster virus

 
 

Herpes Simplex Virus 2 (2X)

This antibody reacts with Herpes Simplex Virus (HSV) 2. HSV 2antibody identifies major viral envelope glycoproteins and core proteins that can be found in the cytoplasm and/or nucleus. HSV can infect both the peripheral and central nervous system. HSV Type 2 infects the genitals and anus.

 

Herpes Simplex Virus 1&2

This antibody cocktail reacts with Herpes Simplex Virus (HSV) 1 and 2. It identifies major viral envelope glycoproteins and core proteins. HSV can infect both the peripheral and central nervous system. It is compatible with formalin fixation; however, prolonged fixation can be detrimental to HSV staining.

 

HPV Cocktail Broad Spectrum

HPV Broad Spectrum was produced against BPV-1 and IH8. It detects HPV-1, 6, 11, 16, 18 and 31 in FFPE specimens. CAMVIR-1 reacts with a protein in cells infected with L1-vaccinia virus and the protein was present in HPV16. Other isotypes may also be reactive with the HPV Broad Spectrum.

 
 

Mycobacterium tuberculosis (TB)

IHC is superior to conventional special stains in the detection of mycobacterium. This antibody is reactive with other mycobacteria species, but is not reactive with E. coli K12, Salmonella typhimurium, Pseudomonas aeruginosa, Streptococcus (group B), Candida albicans and Neisseria meningitides.

 

Treponema pallidum (Spirochete)

Spirochete (Treponema pallidum) is the causative agent of syphilis. Spirochete can now be successfully localized with a treponema pallidum antibody using IHC in FFPE tissue. This rabbit purified IgG fraction is highly specific. Treponema pallidum also cross-reacts with burgdorferi (Lyme disease).

 
 
                                                 
 
   
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